There are many ways that biological theory can inform ethical discussions of genetic engineering and biomedical enhancement. In this essay, we highlight some of these potential contributions, and along the way provide a synthetic overview of the papers that comprise this special issue. We begin by comparing and contrasting genetic engineering with programs of selective breeding that led to the domestication of plants and animals, and we consider how genetic engineering differs from other contemporary biotechnologies such as embryo selection. We (...) go on to consider the implications of genetic engineering for human nature, human evolution, and persistence of the human species. Finally, we question whether genetic interventions warrant the extraordinary ethical scrutiny they are often given, and we show how the misleading “genetic blueprint” metaphor has imposed a faulty structure on the enhancement debate. We conclude by considering the nature of biological development and the sobering limits it places on what genetic engineering can reasonably hope to achieve. (shrink)

Four authors respond to James Rachels' article "Moral Philosophy and as a Subversive Activity.".

A intenção deste artigo é primàriamente exegética. Não pretende chegar a conclusães filosóficas substanciais nem fazer uma apreciação crítica. Pretende simplesmente esclarecer a versão de Russell quanto ao atomismo lógico, apresentando a sua teoria do juízo empírico num contexto histórico. A maior parte dos comentários contemporâneos falham neste ponto; contudo, afigura-se impossível compreender perfeitamente a teoria de Russell aeerca do conhecimento, bem como a Teoria das Descrições, como parte integrante daquela teoria, se não for encarada como uma tentativa (...) para evitar as consequencias de certas teorias alternativas do juízo. Pensa o autor que muitas críticas contemporâneas da Teoria das Descrições estão deslocadas, simplesmente por não conseguirem apreender o papel que aquela teoria devia desempenhar na análise russelliana do juízo empírico. A título de exemplo tenta o autor mostrar como as críticas de P. F. Strawson a respeito da Teoria das Descrições, como foram formuladas no seu artigo On Referring, não vêm a propósito (cf. Secção VT). A principal comparação histórica aqui apresentada refere-se à teoria idealista do juízo de F. H. Bradley. Contudo, parece também importante salientar o acordo que existe entre Russell e Bradley quanto a rejeitar como inadequado o tipo de análise do juízo apresentado por Leibniz e, numa primeira etapa da sua carreira, por G. E. Moore. Leibniz e Moore apresentaram, em moldes diversos, aquilo a que podíamos chamar teorias 'essencialmente genéricas' do juízo. Para Leibniz uma proposição é uma conexão analitica de conceitos, para Moore uma proposição é uma conexão sintética de conceitos. Tanto Russell como Bradley afirmam que é impossível formular uma teoria do juízo satisfatória, se concebermos a relação entre uma mente e uma proposição, implicada no juízo, como uma simples conexao de conceitos. O juízo deve ser apresentado como algo que implica experiência imediata pré-conceitual, experiência essa que, embora em si mesma não seja capaz de verdade ou falsidade, está pressuposta na própria possibilidade de qualquer juízo, verdadeiro ou falso, acerca da realidade. Dum modo geral, podíamos dizer que um juízo, cujo conteúdo é conceitual, é em virtude da experiência imediata que 'atinge a realidade' ('reaches right up to reality'). Contudo, embora Russell e Bradley concordem neste ponto, a análise da experiência imediata apresentada pelo primeiro é muito diferente da do segundo. Na medida em que se pode falar duma tese exegética positiva neste artigo, dir-se-ia que a análise russelliana da experiência imediata, contida na sua doutrina do 'conhecimento por experiência directa' dos particulares na sensação, é formulada especificamente (a) para ser compatível com a existência dum universo pluralista de particulares externamente relacionados e (b) para permitir uma versão da teoria de correspondência da verdade. Por outras palavras, a análise russelliana do juízo empírico, implicando necessàriamente um 'conhecimento por experiência directa' dos particulares na sensação, foi formulada especìficamente para evitar as consequências que, tanto Bradley como Russell, viram seeguir-se da análise idealista do juízo. Isto ilustra uma diferença fundamental entre o método filosófico de Russell e o de Bradley. Bradley aceita o monismo, a irrealidade das relações externas, e a teoria de coerência da verdade como consequência da sua teoria inicial do juízo. Russell, por outro lado, pensa que estas consequências se tornaram inaceitáveis perante a prática e as descobertas da ciência empírica; e tenta, por isso, construir uma teoria do juízo compatível com o tipo de metafísica e com a teoria da verdade, que lhe parece serem exigidos pela ciência empírica. (Resumo do Autor. Trad. A. M.). (shrink)

This essay excavates the pre-capitalist influences of the thought of Guy Debord, French postwar critical theorist and founding member of the Situationist International. Tracing a lineage of what can be described as Debord’s aristocratic sensibility, we discover not simply an aesthetic approach to navigating social life, or guidelines for outmanoeuvring an adversary, but also contempt for honest labour, monetary transactions in cultural affairs, and conventional political gestures. Together these themes remain part of a legacy of an aristocratic past, one that, (...) as will be examined here, informed Debord’s acrimony towards his own mid-20th-century moment. The following discussion will advance a genealogy of Debord’s thinking with these themes from late antiquity to the Italian Renaissance, and finally with an extended examination of the baroque, a concept that helps advance Debord’s diagnostic concept of the society of the spectacle. (shrink)

In the early years of this century the debate as to the nature of judgment was a central issue dividing British philosophers. What a philosopher said about judgment was not independent of what he said about perception, the distinction between the a priori and empirical, the distinction between external and internal relations, the nature of inference, truth, universals, language, the reality of the self and so on.

In the early years of this century the debate as to the nature of judgment was a central issue dividing British philosophers. What a philosopher said about judgment was not independent of what he said about perception, the distinction between the a priori and empirical, the distinction between external and internal relations, the nature of inference, truth, universals, language, the reality of the self and so on.

Wittgenstein’s “Lectures on Religious Belief” (LRB) provide a source for as yet unexplored connections to religious ideas as treated in Robert N. McCauley’s book Why Religion is Natural and Science is Not (2013), and to other CSR scholars who focus attention on how “cognitively speaking it is religion that is natural and science that is largely unnatural.” Tensions are explored in this paper between our “maturationally natural” religious inclinations to adopt religious ideas and the “unnatural” demands sometimes made upon people, (...) either a) by imposition of evidentialist norms over religious utterances, or b) by an agent’s adherence to perceived demands of theological correctness and to a particularly demanding conception of genuine or authentic faith. Wittgenstein uses Bertrand Russell and Father O'Hara to articulate these two tensions, and to offer alternatives which to some degree assuage them. I argue that such tensions are not only illuminating of the more and less helpful models of the relationship between reason and faith, but also open up new research questions which connect contemporary CSR and Wittgensteinian (or more broadly Continental) approaches to philosophy of religion. (shrink)

The ways in which Wittgenstein was directly influenced by William James (by his early psychological work as well his later philosophy) have been thoroughly explored and charted by Russell B. Goodman. In particular, Goodman has drawn attention to the pragmatist resonances of the Wittgensteinian notion of hinge propositions as developedand articulated in the posthumously edited and published work, On Certainty. This paper attempts to extend Goodman’s observation, moving beyond his focus on James (specifically, James’s Pragmatism) as his pragmatist reference (...) point. It aims to articulate the affinity between Wittgenstein’s thought on the topic of certainty and that of the neglected pragmatist thinker, George Santayana. -/- The paper draws on Duncan Pritchard’s recent reading of Wittgenstein’s On Certainty in order to articulate the concept of certainty involved in the notion of hinge propositions. It identifies two important and related points of affinity between this Wittgensteinian line of thought on certainty and the line of thought on the same topic articulated in Santayana’s Scepticism and Animal Faith. The paper argues, firstly, that, both lines of thought reflect a pragmatist concept of certainty, according to which our most fundamental certainties are not conceived as purely theoretical objects of belief or knowledge but rather as thearational presuppositions of beliefs and practical action. Secondly, it examines the way inwhich the pragmatist concept of certainty functions, for the two thinkers as a response to scepticism. It argues that although the two thinkers’ responses are very different, they are mutually compatible and, together, point towards the possibility of a distinctively pragmatist response to scepticism, which involves an anti-epistemological model of the intimate relation of the human self to the world. (shrink)

This chapter contains sections titled: Do Christmas Mythologies Even Exist? The Secular Christmas Mythology: The Santa Story A Sacred Christmas Mythology: The Virginal Conception The Problem of Literal Truth The Philosophical Case Against Literal Truth: Russell's Teapot The Religious Case Against Literal Truth: Tillich's Broken Myths.

This paper will reflect on the possibility of epistemic decolonization, particularly in terms of curriculum, as a transformative educational process in the context of the South African university, and with respect to my own positionality. The argument will centre around two difficult interdependent positions. On the one hand I will argue for the university’s task as transformational, even offering, via Cornel West, the ‘salvific’ possibility that knowledge offers those who seek it. To develop this claim, I will draw on and (...) develop the notion of paideia though the work of Plato and Heidegger.On the other hand, within the postcolonial African university, the question of decolonization in the tertiary space cannot be elided, particularly since the 2015 #RhodesMustFall and #FeesMustFall movements. The university is a powerful colonial relic, and it can be used to reinforce and perpetuate epistemic violence through unreflective or unconscious pedagogical and curriculum decisions. Here I draw on decolonial thinkers such as Santos, Mignolo, Maldonado-Torres, and Mbembe: I argue for a reckoning with the forces of coloniality, and advocate for epistemic justice and criticality, as part of the decolonizing project. In conclusion, working with ideas from Cornel West, I argue to reconcile paideia, as the ‘turning of the soul’, with the decolonizing African university. (shrink)

Paul Davidson has argued that there is little common ground between Post Keynesian analysis and the Austrian approach to economics. He claims that Post Keynesians (unlike Austrian economists) place great importance on the role of expectations and do not present a deterministic view of the economic system. In this essay the validity of such claims is examined.

Presents opposing viewpoints on various ethical, moral, legal, and medical issues concerning euthanasia.

Analyzes the relationship of power, bureaucracy, and change in modern society.

Our thoughts depend on knowledge about objects, people, properties, and events. In order to think about where we left our keys, what we are going to make for dinner, when we last fed the dogs, and how we are going to survive our next visit with our family, we need to know something about locations, keys, cooking, dogs, survival, families, and so on. Researchers have sought to explain how our brains can store and access such general knowledge. A growing body (...) of evidence suggests that many of our concepts are grounded in action, emotion, and perception systems. We appear to think about the world by means of the same mechanisms that we use to experience it. Abstract concepts like ‘democracy,’ ‘fermion,’ ‘piety,’ ‘truth,’ and ‘zero’ represent a clear challenge to this idea. Given that they represent a uniquely human cognitive achievement, answering the question of how we acquire and use them is central to our ability to understand ourselves. This book argues that abstract concepts are heterogeneous and pose three important challenges to embodied cognition. They force us to ask: How do we generalize beyond the specifics of our experience? How do we think about things that we do not experience directly? How do we adapt our thoughts to specific contexts and tasks? It argues that a successful theory of grounding must embrace multimodal representations, hierarchical architecture, and linguistic scaffolding. Abstract concepts are the product of an elastic mind. (shrink)

Comprising specially commissioned essays from some of the most significant contributors to the field, this volume provides a uniquely authoritative and thorough survey of the main lines of Wittgenstein scholarship over the past 50 years, tracing the history and current trends as well as anticipating the future shape of work on Wittgenstein. The first collection of its kind, this volume presents a range of perspectives on the different approaches to the philosophy of Wittgenstein Written by leading experts from America, Britain, (...) and Europe Provides a much needed overview of the complex landscape of Wittgenstein exegesis and Wittgensteinian approaches to philosophy Assesses the current state, aims, and future of Wittgenstein scholarship An essential guide for both students and scholars. (shrink)

In this paper we describe a propagation experiment to measure the one-way velocity of electromagnetic radiation. The experiment utilizes the rotation of the earth to interchange the positions of two rubidium vapor frequency standards over12 h, thereby canceling initial clock phase differences. It is demonstrated that although the drift characteristics of modern rubidium atomic clocks may be large for long-term absolute timing requirements, the short-term random fluctuations are small. It is found that over a24-h period, the long-term drift can be (...) accurately parameterized in retrospect and removed, thereby permitting the detection of temporal variations less than1 nsec in magnitude. With coherent summing techniques this value may be significantly reduced, and it becomes realistic to consider an experiment where the clocks are separated by distances of the order of several hundreds of meters in order to detect velocities of the order of that of the solar system with respect to the center of the galaxy(≈10 5 m sec −1 ), thus ensuring that the rotational motion of the earth has a negligible effect in altering the relative inertial characteristics of the reference frames of each clock. It is demonstrated that under such conditions the measurement of the one-way speed of propagation of electromagnetic radiation is not only meaningful, but can be simply implemented with commercially available instrumentation. (shrink)

Several recent papers which purport to substantiate or negate arguments in favor of certain theories of absolute space have been based on fallacious principles. In this paper we discuss three related instances, indicating where misconceptions have arisen. We establish, contrary to popular belief, that the classical Lorentz ether theory accounts for all the experimental evidence which supports the special theory of relativity. We demonstrate that the ether theory predicts the null results obtained from pulsar timing and Mössbauer experiments. We conclude (...) that a measurement of the one-way velocity of light has physical meaning within the context of the Lorentz theory, and argue that an adequately designed experiment to measure the one-way velocity of light should be attempted. (shrink)

Protective measurements illustrate how Yakir Aharonov's fundamental insights into quantum theory yield new experimental paradigms that allow us to test quantum mechanics in ways that were not possible before. As for quantum theory itself, protective measurements demonstrate that a quantum state describes a single system, not only an ensemble of systems, and reveal a rich ontology in the quantum state of a single system. We discuss in what sense protective measurements anticipate the theorem of Pusey, Barrett, and Rudolph (PBR), stating (...) that, if quantum predictions are correct, then two distinct quantum states cannot represent the same physical reality. (shrink)

This paper formulates generalized versions of the general principle of relativity and of the principle of equivalence that can be applied to general abstract spaces. It is shown that when the principles are applied to the Hilbert space of a quantum particle, its law of coupling to electromagnetic fields is obtained. It is suggested to understand the Aharonov-Bohm effect in light of these principles, and the implications for some related foundational controversies are discussed.

Two notions from philosophical logic and linguistics are brought together and applied to the psychological study of defeasible conditional reasoning. The distinction between disabling conditions and alternative causes is shown to be a special case of Pollock's (1987) distinction between ‘rebutting' and ‘undercutting' defeaters. ‘Inferential' conditionals are shown to come in two types, one that is sensitive to rebutters, the other to undercutters. It is thus predicted and demonstrated in two experiments that the type of inferential conditional used as the (...) major premise of conditional arguments can reverse the heretofore classic, distinctive effects of defeaters. (shrink)

In this article, I begin by describing what I call this Black Lives Matter moment in the US. I then offer three reasons for considering racism as a bioethical issue, the least discussed of which is the way in which racism acts as a barrier to the creation of better healthcare systems. Next, I argue that the concept of race itself constitutes a bioethical issue in a way that is not fully reducible to racism. Finally, I discuss how we, both (...) bioethicists and health care professionals, might meet this moment by identifying individual points of responsibility (beyond liability) for structural injustice. (shrink)

Decision theorists widely accept a stochastic dominance principle: roughly, if a risky prospect A is at least as probable as another prospect B to result in something at least as good, then A is at least as good as B. Recently, philosophers have applied this principle even in contexts where the values of possible outcomes do not have the structure of the real numbers: this includes cases of incommensurable values and cases of infinite values. But in these contexts the usual (...) formulation of stochastic dominance is wrong. We show this with several counterexamples. Still, the motivating idea behind stochastic dominance is a good one: it is supposed to provide a way of applying dominance reasoning in the stochastic context of probability distributions. We give two new formulations of stochastic dominance that are more faithful to this guiding idea, and prove that they are equivalent. (shrink)

The role played by language in our cognitive lives is a topic at the centre of contemporary debates in cognitive (neuro)science. In this paper we illustrate and compare two theories that offer embodied explanations of this role: the WAT (words as social tools) and the LENS (language is an embodied neuroenhancement and scaffold) theories. WAT and LENS differ from other current proposals, because they connect the impact of the neurologically realized language system on our cognition to the ways in which (...) language shapes our interaction with the physical and social environment. Examining these theories together, their tenets and supporting evidence, sharpens our understanding of each, but also contributes to a better understanding of the contribution that language might make to the acquisition, representation and use of abstract concepts. Here we focus on how language provides a source of inner grounding, especially metacognition and inner speech, and supports the flexibility of our thought. Overall, the paper outlines a promising research program focused on the importance of language to abstract concepts within the context of a flexible, multimodal, and multilevel conception of embodied cognition. (shrink)

What is the epistemological role of speech perception in comprehension? More precisely, what is its role in episodes or states of comprehension able to mediate the communication of knowledge? One answer, developed in recent work by Tyler Burge, has it that its role may be limited to triggering mobilizations of the understanding. I argue that, while there is much to be said for such a view, it should not be accepted. I present an alternative account, on which episodes of comprehension (...) are better able to underwrite the interpersonal transmission of knowledge. (shrink)

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IOS Prexs, 2002 Introduction This book is the final project report of the BIOMED II project Ethical Function in Hospital Ethics Committees Commission,-2001 ...

Some disability activists argue that disability is merely a difference. It is often objected that this view has unacceptable implications, implying, for example, that it is permissible to cause disability. In reply, Elizabeth Barnes argues that viewing disability as a difference needn’t entail such implications and that seeing such implications as unacceptable is question-begging. We argue that Barnes misconstrues this objection to the mere difference view of disability: it’s not question-begging to regard its implications as unacceptable, and the grounds that (...) Barnes offers for potentially blocking some of these implications fail to explain our conviction that it’s impermissible to cause disability. (shrink)

Mapping the paths that stem and progenitor cells take en route to differentiate and elucidating the underlying molecular controls are key goals in developmental and stem cell biology. However, with population level analyses it is difficult − if not impossible − to define the transition states and lineage trajectory branch points within complex developmental lineages. Single‐cell RNA‐sequencing analysis can discriminate heterogeneity in a population of cells and even identify rare or transient intermediates. In this review, we propose that using these (...) data, one can infer the lineage trajectories of individual stem cells and identify putative branch points. Clonal lineage tracing of stem cells allows one to define the outcome of differentiation. Integrating these single cell‐based approaches provides a robust strategy for establishing and testing models of how an individual stem cell changes through time to differentiate and self‐renew. (shrink)

I discuss the conjecture that understanding what is said in an utterance is to be modelled as knowing what is said in that utterance. My main aim is to present a number of alter- native models, as a prophylactic against premature acceptance of the conjecture as the only game in town. I also offer preliminary assessments of each of the models, including the propositional knowledge model, in part by considering their respective capacities to sub-serve the transmission of knowledge through testimony. (...) In each case, the preliminary assessment is unfavourable. I end by very briefly sketching an additional model as an object for future consideration. (shrink)

Language pragmatics is applied to analyse problem statements and instructions used in a few influential experimental tasks in the psychology of reasoning. This analysis aims to determine the interpretation of the task which the participant is likely to construct. It is applied to studies of deduction (where the interpretation of quantifiers and connectives is crucial) and to studies of inclusion judgment and probabilistic judgment. It is shown that the interpretation of the problem statements or even the representation of the task (...) as a whole often turn out to differ from the experimenter's assumptions. This has serious consequences for the validity of these experimental results and therefore for the claims about human irrationality based on them. (shrink)